Stickler syndrome is a genetic disorder that affects the connective tissues of the body, leading to a range of physical and medical issues. There are several synonyms for Stickler syndrome, including hereditary progressive arthro-ophthalmopathy, Stickler syndrome type 1, Stickler syndrome type II, and Marshall syndrome. This condition is characterized by joint hypermobility, flat facial features, hearing loss, and skeletal abnormalities, among other symptoms. It is caused by mutations in genes that encode for the production of collagen, which is essential for the strength and elasticity of connective tissue. Although there is no cure for Stickler syndrome, its symptoms can be managed through various medical and therapeutic interventions.