Variola Major is a serious infectious disease caused by the variola virus. It is also known as smallpox and has been eradicated globally, thanks to the smallpox vaccination. However, there are several synonyms used to describe this deadly disease, in both medical and general language. Some of the frequently used synonyms include "spotted fever," "red plague," "black pox," "white pox," and "purple pox." These synonyms describe the appearance of the distinctive rash associated with the disease. Variola Major's symptoms include fever, headache, and body aches, followed by a rash that turns into fluid-filled blisters all over the body. It is a highly contagious disease, and vaccination is the most effective way to prevent its spread.