Leukodystrophy Globoid Cell Early Onset, also known as Krabbe disease, is a rare genetic disorder that affects the nervous system. This debilitating condition leads to the destruction of myelin, the protective covering around nerve cells, resulting in severe neurological symptoms. Although commonly referred to as Krabbe disease, it is crucial to highlight various synonyms for this condition to facilitate better understanding and accurate communication. These synonyms include Krabbe leukodystrophy, globoid cell leukodystrophy, infantile globoid cell leukodystrophy, and early-onset globoid cell leukodystrophy. Recognizing these synonyms ensures effective communication among healthcare professionals, researchers, and individuals seeking information about this devastating disorder. It also aids in spreading awareness and promoting early detection for improved patient outcomes.